Preserving motherhood for when you think you’re actually ready The option of banking embryos, not just for medical reasons but for social factors too, has been a great conduit provided by modern medicine and sciences. Defying the constraints of the natural biological clock, women worldwide have been able to plan better for their pregnancy, and extend their childbearing years through ART and associated options. The process of embryo freezing has been one such breakthrough medical option for childless parents and couples intending to conceive at later stages in life. It has given women from all walks of life the liberty to plan their motherhood through storing embryos for future pregnancies. “This option can give you peace of mind that whatever happens you may be able to have a family in the future,” says a spokesperson of the Human Fertilization and Embryology Authority (HFEA), the fertility watchdog. With ART advancements, women are fortunate enough to deliver healthy babies whenever they want, irrespective of their physical conditions or ambitions in life. But what exactly happens during the process of embryo cryopreservation or embryo freezing? “Embryo cryopreservation is a clinical process that requires a great degree of precision and care. It is the process of freezing and storing embryos in subzero temperatures to preserve their superlative quality. Embryos can remain frozen for a prolonged period and can be thawed to lead to viable pregnancies as and when the couple desires,” says Goral Gandhi, the Founder as well as Scientific and Laboratory Director at Indo Nippon IVF, Mumbai, India. Dr. Goral Gandhi, a leading embryologist has actively worked towards the science of ART and IVF in India, helping numerous women in their journey towards parenthood. Training more than 300 embryologists, she has educated doctors, scientists and embryologists in various aspects of IVF, embryology, and emphasizes on quality care and management in clinical laboratories. In cases when a person may wish to freeze their eggs or use them to plan their later pregnancies, the doctor may recommend In Vitro Fertilization (IVF) or Intracytoplasmic Sperm Injection (ICSI). The process of embryo freezing initiates when the patient intakes hormones to ensure on-time ovulation. Fertility medications also stimulate egg production, which is then left in the laboratory with sperm produces to commence the process of natural fertilization. The fertilized egg- called an embryo, is then monitored by an embryologist, who is vested with the decision to choose a suitable embryo for implantation. For when it comes to embryos, the credibility and accuracy of grading affects the outcome of the pregnancy, therefore, an embryologist plays a crucial role in deciding which embryo(s) to go further with, explains Goral Gandhi, who has done pioneering research work on quality control in laboratories. “If you’re at all considering starting a family and are not necessarily exactly where you want to be for any reason, it’s a good idea to come in and talk to a fertility specialist about freezing embryos, or about other options. So I think knowledge is power and there are a lot of options,” says Kathryn Calhoun, a female infertility specialist at the Atlanta Center for Reproductive Medicine. Embryo cryopreservation has been an effective way for couples who want to welcome pregnancy at later stages of life, or for women who want to preserve motherhood for when they think they are ready to take on the roles of nurturing mothers.
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Doctors and Scientists save lives, but their role goes far beyond than just being healers and life savers. They are the ultimate life-givers, making miracles happen the form of healthy babies to couples that have otherwise lost hope at conceiving. 25th July has been marked as an exceptional date in the history of humankind, with the birth of Louise Brown, the first IVF baby, through the successful intervention of scientists in matters related to infertility. Bringing hope to thousands of other childless couples, more than 8 million IVF healthy babies have been brought into this world through the living field of ART since then. Elucidating on how fulfilling their jobs have proved to be, some of the renowned embryologists talk about how they have helped couples realize their dream of becoming parents. Goral Gandhi, a pioneering name in ART and IVF in India, says, “Embryologists are not just doctors merely following a protocol. It takes a certain dedication and passion for the work that we do, whether it is the QC measures that we so vehemently follow or making the best use of patient material to produce successful chance at pregnancy.” Dr Goral Gandhi has successfully taught embryology to more than 300 students, who share her passion for constantly looking for new ways to help patients through better treatment practices and awareness. Talking about the empowering effect of information and awareness, Goral Gandhi says, “Childless couples who are preparing to bring a child into this world but are affected by infertility related barriers might find great comfort in knowing that they have a medical team of embryologist by their side, to help them experience the joy of parenthood.” The work of an embryologist is mostly behind closed laboratories, where they foster healthy growth of embryos and their eventual culmination into future babies. It is not a typical 9-5 job, rather requires relentless hours of hard work and dedication, but is one of the most unique and fulfilling careers in existence, says Liesl Nel-Themaat, the IVF Lab Director of the University of Colorado Advanced Reproductive Medicine program. With such dedicated scientists each individual’s contribution brings new breakthroughs in approaching infertility. The boundaries of what is possible with IVF and fertility treatment are continually being expanded by these doctors. Crediting the pivotal role of embryologists in bringing assisted reproduction to what it is today, Lareina F. Welch, a leading embryologist, congratulates the doctor worldwide for creating and supporting life. “ This honor wouldn’t be possible without the tireless work of pioneer embryologist and the continued efforts of current day embryologists. To all my colleagues and pioneers in our field, I thank you for your dedication and passion. I wish everyone 100% fertilization on World Embryologist’s Day!” she says. Assisted reproduction depends largely on how the embryos are developed and pre-selected to improve the chances of a successful IVF, and the work of an embryologist revolves around the process. From the point of collecting eggs to transferring embryos, the role of an embryologist is crucial in the entire process of IVF. Ensuring the safety of patients’ fertility materials in the form of egg and sperms, and helping patients improve their chance at pregnancy during an IVF cycle; embryologists help childless parents procreate healthy babies. Surely for couples longing for children, the embryologists act like a ray of hope, but how do they make test tube miracles happen? Critical role of an embryologist during an IVF cycle The process of procreating a future baby in a lab sounds overwhelming but frames the everyday job of an embryologist. In the IVF treatment, an embryologist majorly takes over the process during the phase of egg retrieval. Goral Gandhi, a professional embryologist, who dedicates her time and efforts in helping patients conceive says, “The ultimate objective of any ART procedure is the birth of a healthy baby which can be achieved through an elective single embryo transfer. Our roles require a great degree of precision and care when it comes to patients’ precious genetic material in the form of eggs, sperms and embryos. The process of embryo selection for the best possible IVF results is critical to the role of an embryologist, as our decisions impact a patient’s success with IVF.” Goral Gandhi has actively worked towards the science of ART and IVF in India. Training more than 300 embryologists, she has educated doctors, scientists and embryologists in various aspects of IVF, embryology, and laboratory management. She also conducts ART workshops, including training in IUI, IVF, ICSI, Vitrification, and Trouble Shooting in India, UAE, and Jordon. Explaining the process and the defined role embryologists play, Evelyn E. Neuber, Ph. DCLD (ABB), Clinical Research Coordinator at the Center for Advanced Reproductive Services at UCONN says “During egg retrieval, a doctor collects follicular fluid containing an egg from a patient’s ovary and then hands it to the embryologist who is responsible for isolating the egg from the liquid and preparing it for insemination with the sperm; during embryo transfer, the embryologist loads the embryo onto the catheter and hands it forward to do the MD embryo transfer.” That said, it can be concluded that the main part of professional baby-making, which is embryonic development– from retrieval to maturation, lies under the supervision and control of an embryologist. “Embryologists are fertility experts with a wide-ranging role. We are also critical to a patient’s journey towards parenthood although we work behind the scenes most of the time. For example, we are responsible for fusing the sperm and egg extracted from the patient, hoping that it will lead to successful embryo development. Once the eggs are collected and the sperm is washed and prepared, the embryologist gets to work,” explained Alberto Liñán Tegedor, Director of the IVF laboratory and Embryologist at IVI Middle East Fertility Clinic in Oman. Not only that, but they also perform extended roles by emotionally and medically supporting their patients and offering them the leverage to plan parenthood whenever they want through the process of embryo verification. Thus, embryologists play a key role in delivering happiness to parents through successful pregnancies. It is, however, majorly a result of successful scientific advances and awareness around the help available for couples dealing with infertility that embryologists today see and perform miracles in the form of healthy test-tube babies. By Goral Gandhi - For women, balancing their career and motherhood is a big ask. If we speak statistically, in the early 1980’s women tend to have their first baby at the age of 22. Now by 2000, that average age increased to 25 and till 2019, that age has gone up to 26. Nowadays, women opt for late pregnancies a lot as they are more and more concerned about their career at an early age. The number of women being pregnant after 40 is tripled since 1980 in the United Kingdom. Now, by 2016, the number of a 40-year-old woman giving birth is way higher than a 20-year-old. In the United States, 2.3% of the total birth is given by the woman between 40 to 44 years. You can easily understand now that the society is changing pretty rapidly. But one thing for sure is that the reality of fertility is always the same. Most of the women have their menopausal period in the late ’40s and ’50s. Though it is seen that an older woman may become a mother but conceiving becomes a lot harder for them compared to young ones. Here I am going to share my thoughts on three different categories of women who should certainly opt for the ‘Egg Freezing Procedure’. Single Woman: A single woman Ms. A is born to a liberal-minded and socially forward family. Her parents helped her to acquire a great education and also didn’t force her to marry when her age was advancing. There may be a number of reasons for which Ms. A is not marrying but the most common among them will be she did not find her Mr. Right till now. She can certainly wait to find the hero of her dreams but she also has to think that that will not stop her biological clock which is running out of time. If she likes to have kid later but is still waiting for her Mr. Right, she has to opt for the Egg Freezing Procedure. Career Woman: A happily married woman Mrs. B married her college love at the age of 27. She is an ambitious woman with big goals. She is always focused on her career and will not get time for motherhood when she is at the peak of her career. But the couple always dreams of a child as they are working this hard only to secure a better future for their child. But the path is big enough and certainly will take some time. With her advancing age, her fertility is decreasing; the only way to stop that is via Egg Freezing. After that, she will be tension-free and can work with complete devotion. Medically Unfit Woman: A happily married woman Mrs. C is at the perfect age to start a family with a perfectly fertile partner. But the thing that is blocking her is cancer. With cancer treatments like Chemotherapy and Radiation, the quality of eggs gets affected drastically. But she still wishes of having a child. The best possible thing for which Mrs. C opt for now is without any doubt, Egg Freezing Procedure. Till 2019, thousands of women all around the world have opted to freeze their eggs, which gave them the power to have a child at the right time when they require. They don’t have to think about the biological clock anymore. The process of how women can have their children is truly revolutionized by egg-freezing. I hope the perspective given on 3 major categories of women will help you out in that regard. Goral Gandhi one of India’s leading embryology specialist and IVF trainer & training in India. More than 300 embryologists trained over two decades, across laboratories around the world. Dr. Goral Gandhi is the Founder as well as Scientific and Laboratory Director at Indo Nippon IVF Clinic IVF in Mumbai. India. Infertility comes as one of the most talked about aspects in the medical science today and if we talk about its impact, it has led to big complications in most of the lives around. If we talk about its definition, infertility is largely about the inability of a men or women to conceive even after having unprotected sex for more than one year. The reasons for the same can be miscellaneous and same can be listed form the natural ones to certain lifestyle issues alongside. Infertility treatments Most of the infertility treatments involve the usage of certain fertility medication, medical devices, fertility surgery, or a proper combination of all as per the guidance of an expert physician. Moreover, if the sperm in the men is of good quality along with the properly functioning mechanics of the woman's reproductive structures (patent fallopian tubes, no adhesions or scarring), the IVF specialist may start with the prescription of proper ovarian stimulating medication. The physician might also recommend a conception cap cervical cap, which the couples can brought in use at home by putting the sperm inside the cap and then placing the conception device on the cervix, or intrauterine insemination (IUI), where the doctor then put through the sperm directly into the uterus at the time of ovulation, via a catheter. Within all these methods, fertilization generally occurs within the body and if either of those doesn’t help the couples to achieve a full term pregnancy, the physician might prescribe the patient to undergo in vitro fertilization (IVF) treatment process. IVF and all those related techniques (ICSI,ZIFT, and GIFT) are been termed as assisted reproductive technology (ART) techniques. ART techniques initially commence with the stimulation of the ovaries in order to increase the egg production. Once the stimulation process goes through, the physician extracts one or more eggs from the ovary with the help of surgery, and mixes them with the sperm within a laboratory setting, with the purpose of producing one or more embryos in the process. Fertilization process concludes outside the body, and the fertilized and developed egg is then inserted into the woman's reproductive tract during a process called embryo transfer. There are other medical techniques like tuboplasty, assisted hatching, and Pre-implantation genetic diagnosis which can be brought into use as well. Inception of IVF clinics The best IVF centre indonippon successfully implement the IVF (TEST TUBE BABY) and other ART service (diagnosing and treatment whilst performing IVF, ICSI, PESA and TESA/ICSI/ET) in Kerala is functioning since 1996 at Kadavanthra, Ernakulam. This is where the first children form IVF techniques were born in Kerela in 1997 which were conceived in 1996 from this centre. The centre has facilitated the birth of more than 602 live babies (from IVF /ICSI) till now and the number is ever growing in the current medical environment. Thus, there was always a need of a good IVF centre and Embryologists in Mumbai and other parts of the country and this is where Goral Gandhi has come up as one do the most By Goral Gandhi (Learn IVF Clinic) - Transient motion of embryo transfer-associated antibubbles was observed. This prospective study was performed to determine if this antibubble movement can predict a successful outcome. Transabdominal ultrasound-guided embryo transfers were performed in 187 recipients receiving identical hormone replacement therapy. All embryo transfers were performed by the first author, using the Sureview embryo transfer catheter, in 30 mul of culture media. Observation was made of the catheter placement in relation to the endometrial surface and uterine fundus during embryo transfer. Ultrasound-guided tracking of antibubble within the uterine cavity was done immediately after the piston was depressed at the time of embryo deposition. The antibubble movement was upwards (group A) in 104 embryo transfers and downwards (group B) in 83 transfers. No movement of embryo-associated air out of the uterine cavity, either into the cervix or the intramural portion of the Fallopian tube, was observed. The clinical pregnancy rate was similar in both groups: 47.12% in group A versus 45.78% in group B. The total implantation rate/embryo transferred was 19.34% in group A compared with 20.07% in group B. The movement of the embryo transfer-associated antibubble is unlikely to be a factor in predicting success in donor egg IVF cycles. For More information you can visit here: Embryo Transfers By Goral Gandhi (Indo Nippon IVF) - Progress in the field of assisted reproduction, and particularly micromanipulation, now heralds a new era in the management of severe male factor infertility, not amenable to medical or surgical correction. By overcoming natural barriers to conception, in vitro fertilization and embryo transfer (IVF-ET), subzonal sperm insemination, partial zona dissection, and intracytoplasmatic injection of sperm (ICSI) now offer couples considered irreversibly infertile, the option of parenting a genetically related child. However, unlike IVF, which necessitates an optimal sperm number and function to successfully complete the sequence of events leading to fertilization, micromanipulation techniques, such as ICSI, involving the direct injection of a spermatozoon into the oocyte, obviate all these requirements and may be used to alleviate severe male factor infertility due to the lack of sperm in the ejaculate due to severely impaired spermatogenesis (non-obstructive azoospermia) or non-reconstructable reproductive tract obstruction (obstructive azoospermia). ICSI may be performed with fresh or cryopreserved ejaculate sperm where available, microsurgically extracted epididymal or testicular sperm with satisfactory fertilization, clinical pregnancy, and ongoing pregnancy rates. However, despite a lack of consensus regarding the genetic implications of ICSI or the application and efficacy of preimplantation genetic diagnosis prior to assisted reproductive technology (ART), the widespread use of ICSI, increasing evidence of the involvement of genetic factors in male infertility and the potential risk of transmission of genetic disorders to the offspring, generate major concerns with regard to the safety of the technique, necessitating a thorough genetic evaluation of the couple, classification of infertility and adequate counseling of the implications and associated risks prior to embarking on the procedure. The objective of this review is to highlight the indications, advantages, limitations, outcomes, implications and safety of using IVF/ICSI for male factor infertility to enable a more judicious use of these techniques and maximize their potential benefits while minimizing foreseen complications. For more information you can visit here: in vitro fertilization Goral Gandhi is a Clinical Embryologist with more than 20 years of expertise in the field of IVF and Assisted Reproductive procedures. She is in charge of the structure and foundation of many active assisted conception labs in India and one in Ghana. She is always dedicated to keeping up remarkable achievement rate at all these labs or research centers. In her 22 year’s journey, she has taken care of thousands of IVF and ICSI cases and has helped more than 3500 couples total their families. Goral has a productive involvement in giving training in IVF and has been sorting out academic lectures and hands-on workshops on all parts of IVF including IUI, ICSI, Verification, Trouble Shooting, and Laboratory Management since the year 2000. She has trained more than 350 embryologists from 13 nations. She has set up extremely fruitful Fertility Preservation modules at various labs, and her current research projects are centered around the choice of the most reasonable and ailment free embryo along with the unique conceivable implantation potential using PGD and PGS methods. She has also edited a reading material (textbook) on Verifications. Moreover, she has co-authored more than 30 sections in different therapeutic course books and has a few publications in national and universal journals. If you want to know more about her work, visit Goral Gandhi Website: https://indonipponivf.com/mrs-goral-gandhi/ A doctor who specializes in the reproductive system of women is called a Gynecologist. Surely you have heard that most women, who are adult, visit a gynecologist regularly. It is considered a bit awkward to many people. So naturally, people are curious about it. So here I am about to tell you when and how often we should visit a gynecologist, which is obviously a big question to many of us.
Embryo transfer process is a part of the IVF treatment process and it can said to be the final step in the same process as well. Being a person seeking the IVF treatment, you might have been through weeks of medications, observations along with the egg retrieval process and finally it’s the time when the Embryo is going to be transferred to the uterus of the women after getting developed in a lab for 3-5 days.
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Goral GandhiGoral Gandhi is Scientific and Laboratory Director at Indo Nippon IVF situated in Mumbai, India. Goral Gandhi bragged the position by virtue of her immense knowledge of the IVF and Clinical Embryology. Goral Gandhi has further been a much-admired Clinical Embryologist. Goral Gandhi has a rich experience in imparting education in IVF. Goral Gandhi has co-authored over 30 chapters in various medical textbooks. Why Consult Goral Gandhi?Dr. Goral Gandhi have 25+ Years of Experience, backed by designing and establishment of many successful IVF centres. Dr Goral Gandhi Trained Over 600 Embryologists. Dr. Goral Gandhi is an acclaimed Clinical Embryologist and infertility specialist. Consult Dr. Goral Gandhi on Indo Nippon Ivf Clinic Mumbai.
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